未来几十年内，人类探索利用太空的程度不断加深。2040年，利用空间扭曲技术深入宇宙的“新领域号”消失于海王星附近。2047年，新领域号突然在海王星发回讯号，内容似乎为求救，于是当年设计新领域号的威尔博士受命乘坐营救船“路易与克拉克”号前去施救。船长米勒不甚友好，所幸路易与克拉克号很快按计划与新领域号对接。虽然生命扫描显示新领域号充满生命迹象，但搜寻之后营救队发现所有船员均死亡。
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